Cannabis has been integrated with human civilization for tens of thousands of years. The naturally occurring chemical constituents produced by cannabis exert a profound physiologic effect on both humans and animals. By accessing the endocannabinoid system within the central and peripheral nervous system as well as via other mechanisms throughout the body, cannabis has multiple actions including acting as an anti-inflammatory, analgesic, anti-neoplastic, and anticonvulsant, all the while promoting homeostatic balance.The keys to successfully using cannabis as medicine in veterinary patients lies in understanding the physiology of the endocannabinoid system and how cannabis interacts with it.The legal landscape pertaining to cannabis can be complex and challenging. This webinar sheds light on the history of cannabis, the endocannabinoid system, the current legal hurdles facing the veterinary community and considerations for choosing the right cannabis preparations to successfully treat specific medical conditions.