The objectives of this lecture are to provide a brief summary of updates in conventional diagnostic and treatment options for canine cutaneous mast cell tumors and introduce western biomedical evidence supporting potential benefits of Traditional Chinese Medicine (TCM) herbal therapy in patient care. Molecular diagnostics are now available for obtaining more objective information about behavior in canine mast cell tumors, which can be helpful in determining which patients would benefit from more aggressive anticancer therapy. This information is presented with the vision of beginning to bridge the gap that is often present between “conventional” and “alternative” medicine approaches. Improved communication can benefit patient care and assist practitioners in advising clients regarding potential diagnostic and treatment options that may be desired or beneficial to improving patient outcome.